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	Provedor de dados BJMBR (2) Autor Cam-Etoz,B. (1) Isbil-Buyukcoskun,N. (1) Markus,R.P. (1) Ozluk,K. (1) Zago,W.M. (1) Palavra-chave Mecamylamine (2) Adrenomedullin (1) Atropine (1) Blood pressure (1) Melatonin (1) Methyllycaconitine (1) Neuronal nicotinic acetylcholine receptors (1) Vas deferens (1) Vasopressin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems BJMBR Cam-Etoz,B.; Isbil-Buyukcoskun,N.; Ozluk,K.. Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 µL) caused an increase in both blood pressure and HR (DMAP = 11.8 ± 2.3 mmHg and ΔHR = 39.7 ± 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP8-37) and ADM receptor antagonist (ADM22-52)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenomedullin; Blood pressure; Vasopressin; Atropine; Mecamylamine. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300011 Melatonin modulation of presynaptic nicotinic acetylcholine receptors located on short noradrenergic neurons of the rat vas deferens: a pharmacological characterization BJMBR Zago,W.M.; Markus,R.P.. Melatonin, the pineal hormone produced during the dark phase of the light-dark cycle, modulates neuronal acetylcholine receptors located presynaptically on nerve terminals of the rat vas deferens. Recently we showed the presence of high affinity nicotine-binding sites during the light phase, and low and high affinity binding sites during the dark phase. The appearance of the low affinity binding sites was due to the nocturnal melatonin surge and could be mimicked by exposure to melatonin in vitro. The aim of the present research was to identify the receptor subtypes responsible for the functional response during the light and the dark phase. The rank order of potency of agonists was dimethylphenylpiperazinium (DMPP) = cytisine > nicotine >... Tipo: Info:eu-repo/semantics/article Palavras-chave: Melatonin; Neuronal nicotinic acetylcholine receptors; Mecamylamine; Methyllycaconitine; Vas deferens. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800010 Registros recuperados: 2 Primeira ... 1 ... Última

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